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Mycophenolate mofetil absorption decreased in presence of iron ion preparations
Last Updated: 2001-02-01 16:00:46 EST (Reuters Health)
WESTPORT, CT (Reuters Health) - The concomitant administration of mycophenolate mofetil and iron ion preparations, which are both commonly given to transplant recipients, should be avoided because it results in a significant decrease in mycophenolate mofetil in absorption, according to a report by Japanese researchers.
In the first phase of the trial, Dr. Kazuyuki Ueno, from the National Cardiovascular Center, Osaka, and colleagues gave seven volunteers 1.0 g of mycophenolate mofetil. Next, after a 7-day washout period, the subjects were given 1.0 g of mycophenolate mofetil and two tablets of iron ion preparations. In each phase of the study, Dr. Kazuyuki's group used reverse-phase HPLC to measure the serum concentrations of mycophenolic acid.
Writing in the December 2000 issue of Clinical Pharmacology & Therapeutics, the researchers say that area under the plasma concentration-time curve from 0 to 12 hours for mycophenolic acid was significantly reduced during the second phase of the trial. During the first phase, the mean area under the curve per hour was 32.9 mcg/mL, while it was 2.92 mcg/mL during the second phase.
Further, the maximum concentrations of mycophenolic acid were significantly lower during the second phase of the study. The mean maximum mycophenolic acid concentration per hour during the first phase was 20.1 mcg/mL, compared with 1.30 mcg/mL in the second phase, the investigators note.
Dr. Kazuyuki and colleagues speculate that "the mechanism of interaction between mycophenolate mofetil and iron ion preparation may be the formation of chelation complex; this complex probably restricts gastrointestinal absorption."
Clin Pharmacol Ther 2000;68:613-616.
-Westport Newsroom 203 319 2700
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