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DISEASE STATE	BRAND NAME	GENERIC NAME	PRODUCED BY	SECONDARY INDICATIONS	ADMININ- ISTRATION	COMMON SIDE-EFFECTS	COMMENTS  AND NOTES
ACROMEGALY	Sandostatin	Octreotide	Sandoz 1-800-526-0175	Also used for Carcinoid Syndrome, Vasoactive Peptide Tumor, AIDS associated diarrhea, Gastrinoma	Subcutaneous-SQ or Intravenous-IV	Diabetic patients use caution. Can cause increase or decrease in blood sugar. Other frequent side effects include: Abdominal or stomach pain or discomfort, diarrhea, nausea and vomiting, pain, stinging, tingling, or burning sensation at the place of injection with redness and swelling.	If the patient misses a dose of this medication, use as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and go back to the original schedule. Do not double doses. If the doses are doubled, the symptoms the medication controls (diarrhea) may reappear.The doses should be evenly spaced over 24 hours.
	Sandostatin LAR Depot	Octreotide acetate for injectable suspension	Novartis 1-800-526-0175	Used for patients who can not tolerate Sandostatin. May be used in patients who received radiation and have had an inadequate response	IM (intramuscularly)	Gastrointestinal--diarrhea, flatulence, constipation, nausea, vomiting, hypo/hyperglycemia, hypothyroidism, pain at injection site, hypertension, palpitations, anemia, depression, anxiety, rash	Use this medication with caution in diabetic patients. Do not give the injection into the deltoid muscle-it causes extreme pain.
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ALLERGIC REACTIONS	Benadryl Injection	Diphenhydramine HCl	Parke Davis 1-800-223-0432	Hypersensitivity reactions Type I (immediate type) Antiparkinsonism	IV or deep IM	Drowsiness, sedation, dizziness, faintness, disturbed coordination, postural hypotension	Store at room temperature
	Epipen & Epipen Jr.	Epinephrine 1:1000 (0.3mg) contains sulfites Epinephrine Jr. 1:2000 (0.15mg) contains sulfites	Dey 1-800-755-5560	Emergency treatment of anaphylaxis	IM in thigh	Anxiety, headache, fear, palpitations, local necrosis, drowsiness, anticholinergic effects, pulmonary edema, hypertension, angina, cerebral hemorrhage.	Caution should be used in patients with the following disease states: cardiovascular disease, hypertension, hyperthyroidism, diabetes, pregnancy.
	Solu-Medrol	Methylprednisone sodium succinate	Upjohn 1-800-253-8600	Endocrine and rheumatic disorders, collagen and dermatologic diseases, allergic states, opthalmic and gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, multiple scleroses	IM or IV	Fluid and electrolyte disturbances, GI effects, musculoskeletal effects, dermatologic effects, Neurologic effects, endocrine effect, opthalmic effects, metabolic effects
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ANEMIA	Aranesp	Darbepoetin	Amgen Inc. 1-800-772-6436	For the treatment of anemia secondary to chronic renal failure in dialysis and non-dialysis patients	IV or SC	Vascular access thrombosis, CHF, sepsis, cardiac arrythmias, hypertension, hypotension, infection, myalgia, headache, and diarrhea	Aranesp should not be shaken. It should not be diluted or administered with other solutions. Any unused portion should be discarded.
	Epogen	Epoetin alfa	Amgen 1-800-282-6436	Treatment of anemia associated with chronic renal failure, anemia related to AZT therapy;, anemia in Ca patients on chemotherapy, reduction of allogenic blood transfusions in surgery patients	IV or SQ	Hypertension, headache, tachycardia, nausea, vomiting, clotted vascular access, shortness of breath, hyperkalemia, diarrhea, injection site symptoms, flu-like symptoms, skin rashes	Should not be used for chronic renal failure patients who have severe anemia or anemia caused by iron or folate deficiency. Blood pressure should be monitored in chronic renal failure patients
	Procrit	Epoetin alpha	Ortho Biotech 1-800-325-7504	Anemia associated with end-stage renal disease, anemia at prematurity in preterm infants, treatment of HIV associated anemia, chemotherapy induced anemia.	IV or SQ	Hypertension, headache, tachycardia, nausea, vomiting, clotted vascular access, shortness of breath, hyperkalemia, diarrhea, flu-like symptoms.	Procrit also has an unlabeled side effect of skin rash with renal failure.
	Neupogen	Filgrastim	Amgen 1-800-282-6436	To increase the White Blood Cell Count	IV infusion or SC injection or infusion	Nausea and Vomiting, Skeletal pain, Alopecia, hypertension, rash, peritonitis, renal insufficiency - capillary leak syndrome (rare)	If the patient develops fever or symptoms of infection, contact your physician
	Neulasta	pegfilgrastim	Amgen 1-800-282-6436	To increase the White Blood Cell Count	IV injection or SC injection or infusion	Nausea and Vomiting, Skeletal pain, Alopecia, hypertension, rash, peritonitis, renal insufficiency - capillary leak syndrome (rare). Click here for product information. Click here for Vital Facts.	If the patient develops fever or symptoms of infections, contact your physician.
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AIDS WASTING SYNDROME/ CACHEXIA	Serostim	somatropin	Serono 1-800-283-8088	Treatment of AIDS wasting or cachexia	SQ	Injection site pain, musculoskeletal discomfort and increased tissue turgor (swelling of hands and feet)
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ANTICOAGULANT	Heparin	Heparin	Abbott, Elkins Sinn, Lilly, Fujisawa, Schein….	Prophylaxis and treatment of thrombosis and embolism, diagnosis and treatment of disseminated intravascular coagulation, clotting prevention	SC, intermittent IV, IV	Hemorrhage is the chief complication,local irritation, mild pain, hypersensitivity, chills, fever, urticaria, if stools are tarry contact physician
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ANTICOAGULANT INDUCED PROTHROMBIN DEFIECENCY	Vitamin K Injection	Phytonadione	Merck (AquaMEPHYTON) 1-800-672-6372 IMS (Medeva) (Phytonadione) 1-800-932-1950	Anticoagulant induced prothrombin deficiency; hyproprothrombinemia secondary to conditions limiting absorption or synthesis of Vitamin K; drug induced hypoprothrombinemia due to interference with Vitamin K metabolism	IV,IM, SQ	Allergic reactions: anaphylactic reactions may occur; injection site reactions, transient flushing sensations and peculiar sensations of taste
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CHRONIC HEPATITIS C	Infergen	Interferon-alfacon-1	Amgen 1-800-772-6436	Chronic Hepatitis C	SQ	Anxiety, leukopenia, thrombocytopenia, pain at injection site, neurotoxicity (confusion, depression, trouble concentrating), abdominal pain, flu-like symptoms (aching muscles, fever, chills, headache, nausea and vomiting)	If patient uses drug more than 3x/week--skip dose, if patient uses 3x/week, & misses, take dose next day, wait 2 days, and take next dose & get back on normal schedule, call MD to make aware, (must make sure doses are >48 hours apart), if patient d/n realize dose has been missed until time for next one, then skip that dose, d/n double up
	Intron-A	Interferon Alfa-2b	Schering 1-800-526-4099	Hairy cell leukemia, malignant melanoma, condylomata acuminata, AID'S related Kaposi's Sarcoma, Chronic Hepatitis C (> 18yo), Chronic Hepatitis B (> 18yo), and other unlabeled uses	SQ,IM, or IV infusion	Flu-like symptoms-fever, headache, fatigue, anorexia, nausea and vomiting, photo-sensitivity may occur, dizziness, depression	If patient misses a dose, don’t double up. Contact your physician
	Peg-Intron	Peginterferon alfa-2b	Schering 1-800-526-4099	Treatment of Chronic hepatitus C in patients not previously treated with alpha interferon who have compensated liver diseases and are at least 18 years of age	SC	Mood or behavioral problems, depression , aggressive behavior, low blood pressure, fast heart rate, lowers white blood cells and platelets, flu-like symptom for the first few weeks, tiredness, hair thinning, thyroid problems, appetite problems, (rare serious pain may mean internal organ damage)	If patient misses a dose, don’t double up. Contact your physician
	Rebetron	Interferon alfa-2b and ribaviron capsules	Schering 1-800-526-4099 Other helpful numbers: American Liver Foundation 1-800-GO-LIVER Be In Charge Program 1-888-HEP-2608	Chronic Hepatitis C in patients with compensated liver disease in patients who have relapsed after alfa interferon treatment alone OR in patients previously untreated with interferons	SQ injection and oral capsules	Flu-like symptoms, dizziness, psychiatric symptoms (Depression, etc.), teratogenic effects in pregnancy	If patient misses a dose, don’t double up. Contact your physician
	Roferon-A	Interferon alfa-2a	Roche 1-800-526-6367	Also used to treat hairy cell leukemia	SQ or IM injection	Flu-like symptoms-aching muscles, fever, chills, headache, general discomfort, thrombocytopenia, anemia, leukopenia, tiredness, loss of appetite, nausea and vomiting	If patient misses a dose, don’t double up. Contact your physician
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CHRON'S DISEASE	Remicade	Infliximab	Centocor	Crohn's disease, moderate to severe and fistulizing, Also, newly approved in combination with Methotrexate for inhibition of progression of structural damage in patients with moderate to severe active rheumatoid arthritis in patients who have an inadequate response to MTX.	IV	Infection, IV infusion reactions, nausea, vomiting, fatigue, fever, pain, dizziness, bronchitis, sinusitis, rhinitis, rash, antibody formation, lupus-like syndrome, anaphylaxis.	Patients on Remicade plus Methotrexate report a greater relief from pain and stiffness and a reduction in the number of swollen and tender joints.
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ENDOMETRIOSIS	Lupron	Leuprolide acetate	TAP 1-800-621-1020	Also used for Uterine Leiomyomata, advanced prostate cancer, endometriosis, uterine leiomyomata (fibroids), central precocious puberty	SQ or IM	Hot flashes, gastrointestinal upset, headache, insomnia, other menopausal - like symptoms	May take up to 2 months for cycle to return to normal after lupron therapy is discontinued.
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ERECTILE DYSFUNCTION	Caverject	Alprostadil	Pharmacia and Upjohn 1-800-253-8600	Also used for penile vasculature imaging	Injected into penis	Hypotension, prolonged erection lasting 4-6 hours, testicular pain or edema, pain at injection site
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FERTILITY	Fertinex	Urofollitropin for injection	Serono Labs, Inc. 1-888-398-4567	Used for the development of multiple follices in women participating in an assisted reproductive technology program. Also used for the induction of ovulation in patients with polycystic ovary syndrome and infertility	SQ	Mild to moderate ovarian enlargement or ovarian cysts, redness or swelling at the injection site, severe pelvic pain, nausea, vomiting, and weight gain	If you miss a dose, skip the missed dose.
	Follistim	Follitropin beta for injection	Organon 1-800-631-1253	Used for the development of multiple follices in patients participating in an assisted reproductive technology program.	SQ or IM	Miscarriage, ectopic pregnancy, abdominal pain, injection site pain, vaginal hemorrhage, ovarian cyst.
	Gonal F	Follitropin alfa for injection	Serono Labs 1-888-398-4567	Induction of ovulation and pregnancy in the infertile patient and for the development of multiple follices in patients participating in an assisted reproductive technology program.	SQ	Common side effects include headache, ovarian cyst, nausea, upper respiratory tract infection.
	Humegon	Menotropins for injection	Organon 1-800-631-1253	Induction of ovulation and pregnancy in the infertile patient and for the development of multiple follices in patients participating in an assisted reproductive technology program.	IM	Pulmonary and vascular complications, ovarian overstimulation syndrome, mild to moderate ovarian enlargement, ovarian cysts, abdominal pain, sensitivity to Humegon, GI symptoms, pain, rash, swelling or irritation at site of injection, body rashes, dizziness, tachycardia, dyspnea, tachypnea
	Pergonal	Menotropins for injection	Serono Labs 1-888-398-4567	Induction of ovulation and pregnancy in the infertile patient. Also used to treat hypogonadism in males.	IM	Pulmonary and vascular complications, ovarian overstimulation syndrome, mild to moderate ovarian enlargement, ovarian cysts, abdominal pain, sensitivity to Pergonal, Gastrointestinal symptoms, pain, rash, swelling or irritation at site of injection, body rashes, dizziness, tachycardia, dyspnea, tachypnea
	Pregnyl	Chorionic gonadotropin (hCG) for injection	Organon 1-800-631-1253	Induction of ovulation and pregnancy in the infertile woman who has been appropriately treated with human menotropins.	IM	Headache, irritability, restlessness, depression, fatigue, edema, pain at the site of injection.
	Profasi	Chorionic gonadotropin (hCG) for injection	Serono Labs 1-888-398-4567	Induction of ovulation and pregnancy in the infertile woman who has been appropriately treated with human menotropins. Also used to treat hypogonadism in males.	IM	Headache, irritability, restlessness, depression, fatigue, edema, pain at the site of injection.
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GROWTH HORMONE DEFIECENCY	Genotropin	Somatotropin	Pharmacia and Upjohn 1-800-645-1280	For the long-term treatment of children who have growth failure caused by a lack of adequate endogenous growth hormone secretion. Also used for adults with GHD	SQ	Children-Leukemia has occurred in a small number of children, however the relationship between growth hormone and leukemia is uncertain, injection site pain. Adults- headache, localized muscle pain, weakness, mild hyperglycemia, glucosuria, edema	The injection may be administered in the thigh, buttocks, or abdomen. The injection sites need to be rotated.
	Humatrope	Somatropin	Lilly 1-800-545-5979	For growth failure indicated with chronic renal insufficiency, somatropin insufficiency, and Turner’s Syndrome.	SQ or IM	Development of antibodies, also headache, localized muscle pain, weakness, mild hypoglycemia, glucose in the urine, transient edema during early treatment.	Do not use if the solution is cloudy.
	Nutropin	Somatotropin	Genentech 1-800-626-3553	For growth failure indicated with chronic renal insufficiency, somatropin insufficiency, and Turner’s Syndrome.	SQ	Allergic reaction consisting of skin rash/itching and pain/swelling at the site of injection.
	Nutropin AQ	Somatotropin	Genentech 1-800-626-3553	For growth failure indicated with chronic renal insufficiency, somatropin insufficiency, and Turner’s Syndrome.	SQ	Allergic reaction consisting of skin rash/itching and pain/swelling at the site of injection.
	Nutropin Depot	Long acting somatropin recombinant growth hormone	Genentech 1-800-626-3553	For the long term treatment of growth failure due to a lack of adequate endogenous growth hormone secretion.	SQ	Post injection pain, bruising at injection site, itching at injection sight, redness, nodules at injection site, swelling or puffiness at injection site, 1 to 3 days post dose: headache, nausea, lower extremity pain, fever, vomiting. These reactions are usually self limited and well tolerated.	If within 2 days of scheduled dose, the patient can take dosage. If more than 2 days from scheduled dose, the patient should consult the physician.
	Protropin	Somatrem	Genentech 1-800-334-0290	For primary growth hormone deficiency	SQ or IM	Children-Leukemia has occurred in a small number of children, however the relationship between growth hormone and leukemia is uncertain, injection site pain. Patients may develop antibodies to the medication. Other common side effects include breast growth and pancreatitis.	Missing a dose should not cause the patient harm. If the patient misses a dose of this medication, do not give the missed dose at all and do not double the next one.
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HYPERCALCEMIA	Calcimar	Calcitonin-salmon	Rhone-Poulenc Rorer 1-800-727-6737	Indicated for the treatment of Paget’s Disease, hypercalcemia and postmenopausal osteoporosis	SQ or IM
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MALE HYPOGONADISM	Depo-Testosterone	Testosterone cypionate (in oil)	Upjohn 1-800-253-8600	Also indicated for the treatment of males with delayed puberty and palliation of inoperable breast cancer in women.	IM	Women-virilzation; Males- enlargement of breasts, excessive frequency and duration of penile erections, hair loss, male pattern baldness, acne, seborrhea.
	Pergonal	Menotropins for injection	Serono Labs 1-888-398-4567	Used to treat hypogonadism in males. Also used for the induction of ovulation and pregnancy in the infertile patient.	IM	Pulmonary and vascular complications, ovarian overstimulation syndrome, mild to moderate ovarian enlargement, ovarian cysts, abdominal pain, sensitivity to Pergonal, GI symptoms, pain, rash, swelling or irritation at site of injection, body rashes, dizziness, tachycardia, dyspnea, tachypnea
	Profasi	Chorionic gonadotropin (hCG) for injection	Serono Labs 1-888-398-4567	Induction of ovulation and pregnancy in the infertile woman who has been appropriately treated with human menotropins. Also used to treat hypogonadism in males.	IM	Headache, irritability, restlessness, depression, fatigue, edema, pain at the site of injection.
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MIGRAINE	Imitrex Injection	Sumatriptan	Glaxo Wellcome 1-800-334-0032	To stop acute migraine with or without aura in patients who do not achieve sufficient relief from analgesics. Also relieves nausea and vomiting, photophobia and phonophobia-also used in cluster headaches	SQ	Chest pain, severe- heaviness, tightness of pressure in chest and or neck. Rare-anaphylactic reaction. Also, injection site reaction, difficulty in swallowing, nausea and vomiting, discomfort in jaw, mouth, tongue, throat, nasal cavity or sinuses, dizziness, drowsiness, flushing, lightheadedness, muscle aches, cramps or stiffness, weakness, fatigue, vision changes.	The patient should lie down in a quiet, dark room after injection.
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MULTIPLE SCLEROSIS	Avonex	Interferon beta-1A	Biogen 1-800-456-2255	Relapse/remitting multiple sclerosis	IM	More Common side effects: Flu-like symptoms (recommend Tylenol to help) heart burn, indigestion, sour stomach Less common: hair loss, trouble sleeping	Store refrigerated.
	Betaseron	Interferon Beta-1b	Berlex 1-800-237-5392	Immunomodulator-multiple sclerosis. Unlabeled uses AIDS, AIDS related Kaposi sarcoma, metastatic renal cell carcinoma, herpes of the lips or genitals, malignant melanoma, cutaneous T-cell lymphoma, acute non-A non-B hepatitis	SQ	Injection site reactions, depression, anxiety, emotional problems, depersonalization, confusion; use care in patients with seizures or cardiac disease; photosensitization; flu-like syndrome-use acetaminophen.
	Copaxone	Glatiramer acetate	TEVA & Aventis 1-800-887-8100 or 1-800-633-1610	Indicated for the treatment of relapsing-remitting multiple sclerosis (RRMS). Used to reduce the frequency of relapses in patients with RRMS.	SQ	Injection reactions lasting 15 minutes which consist of flushing, chest pain, palpitations, anxiety, dyspnea, laryngeal constriction and urticaria.
	Solu-Medrol	Methylprednisone sodium succinate	Upjohn 1-800-253-8600	Also used in the treatment of endocrine and rheumatic disorders, collagen and dermatologic diseases, allergic states, opthalmic and gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, multiple scleroses and misc.	IM or IV	Fluid and electrolyte disturbances, musculoskeletal effects, gastrointestinal effects, dermatologic effects, neurologic effects, endocrine effects, opthalmic effects, metabolic effects
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OSTEOARTHRITIS	Hyalgan	Sodium hyaluronate	Sanofi 1-800-223-1062	For the treatment of Osteoarthritis pain in the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics.	Intra-articular injection into the knee	Injection site pain, skin reactions including rash, headache.
	Synvisc	Sodium hyaluronate/ Hylan G-F 20	Wyeth 1-800-666-7248	For the treatment of Osteoarthritis pain in the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics.	Intra-articular injection into the knee	Knee pain or swelling, skin rash, calf cramps, hemorrhoid problems, ankle swelling, muscle pain, tonsillitis with nausea, low back pain.
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PAGET’S DISEASE	Calcimar	Calcitonin-salmon	Rhone-Poulenc Rorer 1-800-727-6737	Indicated for the treatment of Paget’s Disease, hypercalcemia and post-menopausal osteoporosis	SQ or IM
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PROSTATE CANCER	Lupron	Leuprolide acetate	TAP 1-800-621-1020	Indicated for advanced prostate cancer, endometriosis, uterine leiomyomata (fibroids), central precocious puberty	SQ or IM	Hot flashes, gastrointestinal upset, headache, insomnia, and other menopausal - like symptoms.
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RHEUMATOID ARTHRITIS	Enebrel	Etanercept	Immunex 1-800-466-8639	Indicated for the treatment of Rheumatoid Arthritis in patients with inadequate responses to disease modifying antirheumatic drugs.	SQ	Side effects include infections and malignancies, heart failure, heart attack, myocardial ischemia, cerebral ischemia, hypertension, hypotension, cholecystitis, pancreatitis, gastrointestinal hemorrhage, depression, shortness of breath.	Can be used in combination with methotrexate.
	Remicade	Infliximab	Centocor	Used to treat Crohn's disease. Also newly approved in combination with Methotrexate for inhibition of progression of structural damage in patients with moderate to severe active rheumatoid arthritis in patients who have an inadequate response to Methotrexate.	IV	Infection, IV infusion site reactions, nausea, vomiting, fatigue, fever, pain, dizziness, bronchitis, sinusitis, rhinitis, rash, antibody formation, lupus-like syndrome, anaphylaxis.	Can be used in combination with methotrexate.
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RESPIRATORY SYNCITIAL VIRUS	Synagis	Palivizumab	Medimmune 1-800-934-7426	Used to treat Respiratory Syncitial Virus (RSV). Also, used to prevent serious lower respiratory tract disease caused by RSV in pediatric patients at high risk.	IM	Frequent side effects include cough, wheezing, bronchiolitis, pneumonia, bronchitis, asthma, croup, shortness of breath, sinusitis, apnea, failure to thrive, nervousness, diarrhea, vomiting, gastroenteritis, liver function abnormality, injection site reaction, conjunctivitis, and viral infections.
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Prepared 12.19.01 by An’trese Critchlow, MS, PharmD candidate

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