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Male factor infertility is the cause of approximately 40% of all cases of infertility¹. Male factor infertility can stem from a number of issues ranging from a problem with sperm quality to hormonal imbalances. There are limited treatment options available for male factor infertility, therefore couples are searching for alternative therapies. Recently, most of the attention has centered on a product known as Proxeed.

ProXeed is a dietary supplement being marketed on the Internet for the treatment of certain types of male factor infertility. Keep in mind that ProXeed, like all natural products, has not been evaluated or approved by the FDA. We have therefore prepared the following guide to provide you more information on the theory, use, and effectiveness of this supplement.

What is ProXeed?

ProXeed is a nonprescription nutritional supplement marketed by Sigma Tau Pharmaceuticals as a fertility aid for men. The product is believed to contribute to a man’s overall reproductive health by improving sperm quality. ProXeed’s main active ingredients include two forms of L-carnitine: L-carnitine fumarate and acetyl-L-carnitine.

What is L-carnitine?

L-carnitine is a substance found in animal foods such as meat and milk. It is also naturally produced by the liver from amino acids that are present in our bodies. The normal individual’s body will make enough carnitine to support its daily needs, however strict vegetarians may require supplementation. L-carnitine, and one of its metabolites acetyl-L-carnitine, play an important role in the body by transporting fatty acids into cells for use in energy production.

What is the role of L-carnitine in treating male infertility?

Researchers have found that L-carnitine is found in much greater amounts in sperm tissues than other cells. Preliminary studies suggest that L-carnitine and acetyl-L-carnitine may be able to stimulate sperm motility in certain situations. The role of L-carnitine on sperm maturation and sperm quality however, is still unclear. ProXeed is believed to work by supplying additional L-carnitine and acetyl-L-carnitine to men who may have inadequate amounts in their sperm.

Several clinical studies have evaluated the effect of L-carnitine on men with a low sperm count, a reduction/loss in sperm movement, or men with both conditions. These studies have evaluated only small numbers of men who took oral carnitine supplements for varying lengths of time. Some patients enrolled in these studies experienced increased sperm counts and/or increased sperm motility, however it is still too early to determine the benefit of L-carnitine supplementation.

Is there any proof that taking ProXeed actually helps in achieving a pregnancy?

No studies have been conducted to evaluate the likelihood of pregnancy with L-carnitine products. Further investigation will be necessary before the role of L-carnitine in the treatment of male infertility can be determined.

Does ProXeed have any known side effects?

No side effects have been reported in clinical studies that evaluated the effects of L-carnitine, the main ingredient in ProXeed, on sperm. Side effects have been reported in patients who took this supplement for L-carnitine deficiency. These were generally mild and included transient nausea, vomiting, abdominal cramps, and diarrhea. Drug-related body odor was also reported in a small number of patients.

The bottom line with ProXeed:

• Small studies evaluating the effect of L-carnitine and acetyl-L-carnitine have shown that these substances may improve sperm motility and/or increase sperm counts. However, a correlation between enhanced sperm motility from taking carnitine-containing products and likelihood of pregnancy has not been demonstrated.
• There are no studies available showing increased pregnancy rates for couples where the male was taking ProXeed or any L-carnitine supplement.
• L-carnitine and acetyl-L-carnitine are not solutions for every type of male infertility, therefore always seek medical advice before beginning any treatment program.

References:

Information in this Web site is intended to supplement, not replace, the medical advice you receive from your healthcare providers. If you have a question regarding any information contained in this Web site and how it pertains to your personal condition, please consult your physician.

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